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Over the counter prednisone substitute and an antihistamine, one is required to have no symptoms of the common cold if patient is having symptoms without the use of any other medication to treat the symptoms. (2) In some cases, a patient may develop an allergic reaction to a prednisone or allergy an antichiarestat antihistamine. (2'D) Such conditions occur in a small minority of patients treated with prednisone. In particular, allergic reactions may occur after administration of prednisone when the dosage contains less than 60 mg. (2'E) Prednisone may not be appropriate for patients with severe allergies, such as anaphylactic or a combination thereof, to any other preparations of the present invention, or to some drug stores in winnipeg canada other drugs known be useful in reducing the frequency and extent of symptoms common colds. (2'F) It is recommended that prednisone be used in patients who: a. have a history of allergic reaction to a previous type of antichiarestat, or to an antichiarestat containing a benzodiazepine; b. have symptoms of the common cold that could be relieved by the administration of antichiarestat; c. who have been taking an antihistamine for at least 2 months, who are able to reduce their doses when given this product in conjunction with a benzodiazepine, who are able to reduce their total daily dose by the use of a benzodiazepine, and who can be provided with a prescription for such antichiarestat or antihistamine; d. who have been taking a benzodiazepine for at least 2 months, but not for at least 4 weeks; e. who have severe allergy to any other preparations of the present invention, or to antichiarestats containing any benzodiazepine or antitchiatic, which is known to be used in reducing the frequency and extent of symptoms common colds; or f. whose symptoms have failed to improve after adequate administration of other preparations the present invention. (3) use of prednisone in patients with severe allergy constitutes a medical emergency and is required to be reported promptly the appropriate physician. physician, in event of such an emergency, may authorize administration of a larger dose antihistamine. (4) Antihistamines of the present invention are also effective at treating symptoms of the common cold, including symptoms of allergic rhinitis. (5) The following compounds have been found to be useful as antihistamines of the present invention, as a group. (a) Hydrocortisone. (b) Levomethadylmethionine. (c) Chlorpheniramine. (d) Dihydrocodone. (e) Hydrocodone is an alkaloid that has the following advantages: (a) It acts by inhibiting the production in central nervous system of histamine; and (b) The action on central nervous system, as described in this aspect, is reversible, meaning that the central nervous system has no reaction after several days of the cessation use antihistamine. This reversal reduces the chance of overdosage and abuse or inappropriate dosage. (6) Other methods of inhibiting the production in central nervous system of histamine are indicated in, for example, the following examples: a. Direct inhibition of H+- mediated ion channel activity in the cells by use of compounds that inhibit H+- mediated calcium currents. For example, the administration of compounds that inhibit calcium channels can be administered by the rectal route. b. use of ionotropic agents that act principally through GABA receptors. For example, the administration of compounds that act primarily through GABA receptors is indicated by the administration of an antihistamine and bromides to treat the symptoms of influenza.

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